SmartType

The Smarter Way to Karyotype

 

SmartType works with almost any microscope and any camera.

Just import your metaphase images direct into SmartType.

Get SmartType

Features

 

SmartType is a powerful simple to use karyotyping system for routine diagnostic or research use.  SmartType provides ergonomically efficient tools to simplify the editing process even for metaphases exhibiting poor morphology as often seen with leukemic samples. Powerful trainable classifiers automate much of the classification process with any final corrections being made with a simple drag-and-drop.

 

SmartType can be used with any microscope and any camera capable of capturing and saving images of metaphases. The intuitive user interface and excellent use of the available screen space makes karyotyping a breeze even if you are working on a smaller screen such as laptop.

 

  • Interactive tools that can be tailored whilst being used to work the way you do.
  • Chromosome tints for easy chromosome identification.
  • Interactive composite table view with drag and drop reclassification
  • Multiple karyotypes open side-by-side for easy comparison.
  • Multiple species support.
  • Extensible patient data and flexible report generation
  • G, R, Q & Dapi banding classifiers.
  • Trainable classifiers.
  • Stitch multiple images to extend field of view.
  • Multi step Undo.
  • Runs on PC Windows and Apple OS-X.
  • Fully networkable.

Editing Tools

 

SmartType’s editing tools makes light work of creating a karyotype. SmartType tools automatically separate touching and overlapping chromosomes. For difficult to separate overlaps and clusters, manual editing tools have been ergonomically designed to get the job done with the minimum of fuss. Colourful highlighting is used to keep the user informed of his exact stage in the editing process. There are tools to separate clusters, resolve overlaps, extend boundaries, join parts, fill holes, erode and dilate. Novice or expert, it’s reassuring to know that SmartType allows you multiple undo steps. Even after saving, the karyotype can always be re-opened for editing.

 

(click on image to play video)

 

 

Classifiers & Layouts

SmartType automatically classifies chromosomes according on their size and or morphology. Any misclassified chromosomes are easily corrected with drag and drop.

 

SmartType uses a trainable classifier. This means we can teach it to recognise a new species by presenting it with karyotypes that have been correctly manually classified with SmartType. In this way if an automatic classifier for the species you are working on is not already part of SmartType, we can create one for you from karyotypes that you have created manually using SmartType.

 

SmartType supports multiple species: human, bird, cattle, dog, horse, mouse, pig and zebrafish.

 

(click on image to play video)

Work Flow

SmartType is designed to integrate with laboratory workflow. Karyotypes are organised into cases with associated user defined case information such as patient details, comments. Each new karyotype can inherit information from the case details avoiding tedious re-entry of patient information.

 

Print reports can be generated and customised for your specific laboratory requirements.

Species Support

SmartType supports a variety of different species. Each species can have a layout, ideograms and classifiers.

 

SmartType currently supports the following species:

 

  • Human: layout, ideograms, auto-classifiers
  • Bird: layout, no ideograms, classify by size
  • Cattle: layout, ideograms, classify by size
  • Dog: layout, ideograms, classify by size
  • Horse: layout, ideograms, classify by size
  • Mouse: layout, ideograms, classify by size
  • Pig: layout, ideograms, auto-classifier
  • Zebrafish: layout, ideograms, classify by size

 

Hardware

We offer the Motic BA410 Elite microscope together with carefully matched components including camera, objectives, filters and c-mount for a cost effective optimum solution for G-band karyotyping.

 

A complete system including computer can be provided.

Clients

 

  • Great Ormond Street Hospital &
  • Institute of Child Health (London, UK)
  • The University of Sheffield (Sheffield, UK) (Educational Use)
  • Kuster Research Porcine Fertility Studies (Illanois, USA)
  • Universidad Nacional de San Luis (Argentina)
  • GerMedTech Clinical Use (Ukraine, Odessa)
  • Afgen (Azerbaijan)
  • Neoscreen E.P.E. (Athens, Grece)
  • Cefegen (Madrid, Spain)
  • Sanger Centre (Cambridge, UK)
  • University of Kent (Canterbury, UK)
  • University of Birmingham - BioSciences) (Birmingham, UK)
  • University of Birmingham - Inst. of Biomedical Research (Birmingham, UK)
  • Chrombios (Berlin, Germany)
  • Genus, Winsconsin, USA
  • Florida International University (Miami, USA)
  • Unithon CA (Maracaibo, Venezuela)
  • Institute of Basic Medical Sciences (Beijing China)
  • Dubai Equine Hospital (Dubai, UAE)
  • Monash University (Clayton, Australia)
  • Curtin University (Bently, Australia)
  • Ontario Veterinary College (Guelph, Canada)
  • International Inst Molecular & Cell Biology (Warsaw, Poland)

SmartMarker

 

SmartMarker is an application intended for use in education to automatically grade karyotypes produced by students.

 

With SmartMarker the lecturer produces a karyotype of a metaphase (the reference karyotype), s/he then distributes the same metaphase to the students who produce their own karyotypes.  SmartMarker compares the students' karyotypes with the reference karyotype and produces a detailed report for each student's karyotype. We hope it could save you a lot of time marking!

 

SmartMarker can be dowloaded from here.

 

Download and unzip the SmartMarkerDistribution.zip read the SmartMarker User manual

SmartMarker is still in beta release. Contact us if you are interested in trying it..